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Indications about Power x Tablets in Pakistan

Indicated for the treatment of premature ejaculation (PE) in men 18 to 64 years of age, who have all of the following:

Persistent or recurrent ejaculation with minimal sexual stimulation before, on or shortly after penetration and before the patient wishes.

Marked personal distress or interpersonal difficulty as a consequence of PE and poor control over ejaculation.

Power x Tablets in Pakistan for Erectile Dysfunction

Pharmacology

The mechanism of action is thought to be related to inhibition of neuronal reuptake of serotonin and subsequent potentiating of serotonin activity. The central ejaculatory neural circuit comprises spinal and cerebral areas that form a highly interconnected network. The sympathetic, parasympathetic, and somatic spinal centers, under the influence of sensorygenital and cerebral stimuli integrated and processed at the spinal cord level, act in synergy to command physiologic events occurring during ejaculation. Experimental evidence indicates that serotonin (5-HT), throughout brain descending pathways, exerts an inhibitory role on ejaculation. To date, three 5-HT receptor subtypes 5-HT (1A), 5-HT (1B), and 5-HT (2C) have been postulated to mediate 5-HT's modulating activity on ejaculation.

Dosage & Administration of Power x Tablets in Pakistan

Adult (18 to 64 years of age): The recommended starting dose for all patients is 60 mg, taken as needed approximately 1 to 3 hours prior to sexual activity. If the effect of 30 mg is insufficient and the side effects are acceptable, the dose may be increased to the maximum recommended dose of 60 mg. The maximum recommended dosing frequency is one dose every 24 hours.

Interaction of Power x Tablets in Pakistan

CNS active medicinal products: The use of Power x Tablets inPakistan in combination with CNS active medicinal products has not been systematically evaluated in patients with premature ejaculation. Consequently, caution is advised if the concomitant administration of Power x Tablets in Pakistan and such medicinal products is required.

PDE5 inhibitors: Tadalafil did not affect the pharmacokinetics of Power x Tablets in Pakistan. Sildenafil caused slight changes in Power x Tablets in Pakistan pharmacokinetics, which are not expected to be clinically significant. However, Power x Tablets in Pakistan should be prescribed with caution in patients who use PDE5 inhibitors due to possible reduced orthostatic tolerance.

Tamsulosin: Concomitant administration of single or multiple doses of 30 mg or 60 mg Power x Tablets in Pakistan to patients receiving daily doses of Tamsulosin did not result in changes in the pharmacokinetics of Tamsulosin. However, Power x Tablets in Pakistan should be prescribed with caution in patients who use alpha adrenergic receptor antagonists due to possible reduced orthostatic tolerance.

Warfarin: There are no data evaluating the effect of chronic use of Warfarin with Power x Tablets in Pakistan; therefore, caution is advised when Power x Tablets in Pakistan is used in patients taking Warfarin chronically.

Ethanol: Concomitant use of alcohol and Power x Tablets inPakistan could increase the chance or severity of adverse reactions such as dizziness, drowsiness, slow reflexes, or altered judgment. Combining alcohol with Power x Tablets in Pakistan may increase these alcohol-related effects and may also enhance neurocardiogenic adverse events such as syncope, thereby increasing the risk of accidental injury; therefore, patients should be advised to avoid alcohol while taking Power x Tablets in Pakistan.

Contraindications with Power x Tablets in Pakistan

Patients with known hypersensitivity to Power x Tablets in Pakistan Hydrochloride.

Patients with significant pathological cardiac conditions such as heart failure (NYHA class II-IV), conduction abnormalities (second or third degree AV block or sick sinus syndrome) not treated with a permanent pacemaker, significant ischemic heart disease of significant alular disease.

Concomitant treatment with monoamine oxidize inhibitors (MAOIs), thioridazine. Similarly, MAOIs or thioridazine should not be administered within 7 days after Power x Tablets in Pakistan has been discontinued.

Concomitant treatment with serotonin reuptake inhibitors (SSRIs), serotonin-nor epinephrine reuptake inhibitors (SNRIs), tricycle antidepressants (TCAs) or other medicinal/herbal products with serotonergic effects or within 14 days of discontinuing treatment with thesemedicinal/herbal products.

Side Effects of Power x Tablets in Pakistan

Dizziness, Headache, Somnolence, Tremor, Blurred vision, Tinnitus, Sinus congestion, Nausea, Diarrhea, Abdominal pain, Dry mouth, Fatigue, Insomnia, Hypertension.

Pregnancy & Lactation using Power x Tablets in Pakistan

Power x Tablets in Pakistan is not indicated for use by women. It is not known either Power x Tablets in Pakistan or its metabolites are excreted through human breast milk.

Precautions about Power x Tablets in Pakistan

Patient with bleeding disorders, epilepsy, susceptibility to angle-closure glaucoma or raised intraocular pressure. Not intended for use in women. Known CYP2D6 poor metabolize.

Overdose Effects of Power x Tablets in Pakistan

There were no unexpected adverse events in a clinical pharmacology study of Power x Tablets in Pakistan with daily doses up to 240 mg. In general, symptoms of overdose with SSRIs include serotonin-mediated adverse reactions such as somnolence, gastrointestinal disturbances such as nausea and vomiting, tachycardia, tremor, agitation and dizziness. In cases of overdose, standard supportive measures should be adopted as required.

Storage Conditions of Power x Tablets in Pakistan

Store below 30°C. Protect from light and moisture. Keep out of reach of children

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